"The Stars are Right."
The words chill you to the bone, not because they were written in blood by the black-robed man that now lies dead before you, but because of their implication.
They herald the end of existence, for you, for your friends, and for the Earth. The end of everything.
During step 5 or setup ("Determine Ancient One") Set up the Mystic Ruins Encounter deck.
If Syzygy is not the Ancient One, set aside all Cosmic Alignment Adventures; then draw the Discovery of a Cosmic Syzygy Adventure and spawn 1 Gate.